|
rs266729
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
T2D was significantly associated with promoter rs266729, rs17300539, rs1884613, rs2144908, and rs4810424, and the association of T2D risk were affected by study population, diagnostic criteria, and genotype methods.
|
30860284 |
2019 |
|
rs266729
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
|
rs1501299
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM.
|
31128439 |
2019 |
|
rs1501299
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population.
|
31755094 |
2019 |
|
rs1501299
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two individual polymorphisms (ADIPOQ rs1501299, KCNJ11 rs5219) were found to be associated with T2D.
|
30467975 |
2019 |
|
rs17300539
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Meta-analysis showed only rs266729 and rs17300539</span> of ADIPOQ, and rs1884613, rs2144908, and rs4810424 of HNF4A were significantly associated with T2D risk.
|
30860284 |
2019 |
|
rs182052
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Prevalence of type 2 diabetes mellitus was higher in subjects with the rs182052 A allele (OR = 2.29; 95%CI 1.29-4.21; <i>p</i> = 0.024).
|
31561637 |
2019 |
|
rs822396
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population.
|
31755094 |
2019 |
|
rs17366743
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The goal of the study was to assess associations of rs17300539, rs266729, rs182052, rs2241766, and rs17366743 single nucleotide polymorphisms (SNPs) of the <i>ADIPOQ</i> gene with concentrations of serum adiponectin and with coronary atherosclerosis and type 2 diabetes mellitus in 447 patients (316 men and 131 women) subjected to coronary angiography.
|
31561637 |
2019 |
|
rs2241766
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control study was conducted to assess the association of rs2241766 and rs822395 SNPs of adiponectin gene (ADIPOQ) with T2DM in Iraqi population.
|
29627525 |
2018 |
|
rs2241766
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2241766T>G SNP of adiponectin gene is a risk factor for the development of T2DM in Iraqi population and directs the changes of serum lipid concentrations as well as insulin resistance.
|
29627525 |
2018 |
|
rs2241766
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
|
29686595 |
2018 |
|
rs16861194
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, due to the limited sample size, only the rs16861194 exerted a significant increased risk on T2DM.
|
29101068 |
2018 |
|
rs822395
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case-control study was conducted to assess the association of rs2241766 and rs822395 SNPs of adiponectin gene (ADIPOQ) with T2DM in Iraqi population.
|
29627525 |
2018 |
|
rs266729
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sources of control populations were the cause of between-study heterogeneity; nonetheless, there was no publication bias among studies.The G allele of rs266729 in adiponectin gene increases the risk of T2DM through an additive genetic model with an effect of 1.13 (1.06, 1.19).
|
29381968 |
2017 |
|
rs266729
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we found an effect modification of obesity on the association between the ADIPOQ rs266729 SNP and total cholesterol (P = 0.00068) only in obese participants after adjusting for age, gender, BMI, and T2D status.
|
27388775 |
2016 |
|
rs2241766
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study, the associations of rs2241766 T/G of ADIPOQ, rs9289231 T/G of KALRN, and rs9939609 A/T of FTO polymorphisms with genetic susceptibility to CAD in type 2 diabetic (T2D) patients were investigated.
|
27218147 |
2016 |
|
rs2241766
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results show that T45G and G276T polymorphisms of ADPN are associated with a significantly elevated risk of DPN in T2DM patients, likely by down-regulating ADPN serum level.
|
26144281 |
2016 |
|
rs1501299
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs1501299
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study observed that the SNPs rs3792267 in CAPN10, rs1501299 in APM1, and rs3760776 in FUT6 might serve as potential susceptible biomarkers for T2DM in Uyghurs.
|
27374856 |
2016 |
|
rs17300539
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs16861194
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
When T2D cohort was further stratified according to the obesity status, PPARγ2 (rs1801282) and FTO (rs9939609) showed association with T2D only in the obese diabetic group and ADIPOQ (rs16861194) showed no difference in risk of susceptibility to the disease.
|
26243686 |
2016 |
|
rs182052
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, the synergistic interaction between β-HCH and r</span>s182052 significantly increased T2DM risk (OR <sub>I-additive model</sub> = 2.20, OR <sub>I-recessive model</sub> = 2.13).
|
27883041 |
2016 |
|
rs822393
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
To investigate the association between two single nucleotide polymorphisms (SNPs; rs3774261 and rs822393) in the ADIPOQ gene and type 2 diabetes mellitus in Han Chinese from northeast China.
|
27181706 |
2016 |
|
rs3774261
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GG genotype of rs3774261 increased the risk of type 2 diabetes mellitus compared with the AA genotype in participants with a body mass index <24 (P = 0.021; odds ratio 1.636, 95% CI 1.708-2.484).
|
27181706 |
2016 |